Dr. Muhammad Usman

Assistant Professor
B.Pharm (PU, Pakistan); M.Phil Pharmacology (UVAS); PhD Clinical Pharmacy (Germany).
Tel: 00 92 42 9921 1449 (Ext 314)
Mobile: +923334548265
Email: usman.ips@uvas.edu.pk

Biography

Dr. Muhammad Usman, is Assistant Professor at Institute of Pharmaceutical Sciences (IPS), University of Veterinary & Animal Sciences, Lahore, Pakistan. He got B.Pharmacy degree from University of the Punjab in 2005 and M.Phil in Pharmacology and Toxicology from University of Veterinary and Animal Sciences, Lahore in 2008. He went to Germany in 2013 and completed his doctoral degree in December 2016 from University of Muenster, Germany.
He started his professional career in Feb 2006 as Community Pharmacist and served at Himont Pharmacy Gujranwala as Branch Manager for 9 months. Then he joined Doctor’s Hospital and Medical Centre as retail Pharmacist on 02-11-2006 and worked till 07-11-2008.
Immediately after completion of his M.Phil in 2008 he joined Institute of Pharmaceutical Sciences, UVAS as Lecturer on 08-11-2008 and was a member of pioneer team in the establishment of this esteemed Institute.
He is also a part of Bioequivalence Study Center (BeSt Center), UVAS, Lahore. He is skillful in conducting clinical trials for Bioequivalence studies and quantification of drugs in biological fluids through HPLC.
The research title of his M.Phil Thesis was “Comparative pharmacokinetics of Levofloxacin in Healthy Volunteers and in Patients Suffering from Typhoid Fever”. During M.Phil he got hands on training of clinical trials and quantification of drug concentrations in human plasma by using HPLC.
The area of research in Doctoral study is Population Pharmacokinetics in Elderly Patients. He got a good experience of working on different Pharmacokinetic software including NONMEM® and PK-Sim®. He is the Pioneer Pharmacometrician who is introducing this technique in Pakistan and has developed Pakistan’s 1st ever Pharmacometrics Laboratory at IPS, UVAS. He has also represented Pakistan as Pharmacometrician at different scientific forums in Pakistan and across the globe.

Areas of Interest

  • Population Pharmacokinetics (popPK) modelling
  • Physiologically Based Pharmacokinetics (PBPK)
  • Quantification of drug concentrations in biological fluids by HPLC, LC-MS, Immunoassays
  • Quantification of drugs in blood by Dried Blood Spot (DBS) technique.
  • Bioequivalence studies
  • Pharmacovigilance
  • Availability of essential medicines

Publications


  • Book of thesis published by VDM-Verlag as (1st author) Titled “Comparative Pharmacokinetics of Levofloxacin in Healthy Volunteers and in Patients Suffering from Typhoid Fever” ISBN # 978-3-639-24818-0
  • Book of thesis published by VDM-Verlag as (3rd  author) Titled “Development Of Analytical Technique For The Determination Of Metronidazole In Commercially Available Suspensions” ISBN # 978-3-639-27714-2
  • Usman M, Rasheed H, “Pharmacometrics and its application in clinical practice” Encyclopaedia of Pharmacy Practice and Clinical Pharmacy, Babar, Z-U-D (2019). Ed.1st Vol 3B: 227-238. ISBN: 9780128127353.
  • Usman M, Rasheed H, Clinical pharmacokinetics and therapeutic drug monitoring, Encyclopaedia of Pharmacy Practice and Clinical Pharmacy, Babar, Z-U-D (2019). Ed.1st Vol 3A:8-19. ISBN: 9780128127353 Ed.1st Vol 3:8-19
  • Rasheed H, Nawaz MA, Usman M, Anjum SM, Epilepsy-role of pharmacist in management and control, Encyclopaedia of Pharmacy Practice and Clinical Pharmacy, Babar, Z-U-D (2019). Ed.1st Vol 3A:598-618, ISBN: 9780128127353

 

  1. Saleem R, Khan H.M, Usman M*, Khokhar M.I, Rasheed H, Abbas M, Khan R.R, Maqsood Z, Zaman M (2021). Population Pharmacokinetics of Ciprofloxacin in Pakistani Patients Suffering from Enteric Fever: International Journal of Clinical Pharmacology and Therapeutics. 59(1): 47-57 DOI 10.5414/CP203823
  2. Khan Q, Siddique MI, Rasool F, Naeem M, Usman M, Zaman M (2020). Development and characterization of orodispersible film containing cefixime trihydrate. Drug Development and Industrial Pharmacy. 46(12): 2070-2080 DOI 10.1080/03639045.2020.1843477
  3. Waqas MK, Ali R, Usman M, Shahid MN, Rasul A, Khan BA, Murtaza G (2020). In Vitro Comparative Dissolution Assessment of Different Brands of Co-Amoxiclav Tablets in Pakistan. Dissolution technologies. 27(4): 1-8 dx.doi.org/10.14227/DT270420PGC1
  4. Ali M, Usman M*, Rasheed H, Hempel G, Nawaz HA, Hanif M, Rasool F, Saleem M (2020). A systematic review on chromatography based method validation for quantification of vancomycin in biological matrices: Bioanalysis. 12(24):1767-1786 DOI: 10.4155/bio-2020-0230
  5. Zaman M, Khan H.M, Usman M*, Khokhar M.I, Rasheed H, Khan R.R, Abbas M, Saleem R (2020). Population pharmacokinetics of meropenem among post-operative patients in Pakistan: International Journal of Clinical Pharmacology and Therapeutics (Accepted)
  6. Khadka S, Hashmi F.K, Usman M (2020). Preventing COVID-19 in Low and Middle income countries. Drugs & Therapy Perspectives 36: 250-252
  7. Nawaz HA, Masood MI, Abbas M, Usman M, Khan AM, Rasheed H and Riffat S. 2019. Evaluation of gender difference in pharmacokinetics of Candesartan cilexetil in the fasted state by RP-HPLC: A single dose comparative study. Pak J Pharm Sci. 32(3): 1019-1024.
  8. Rasheed, H., M. Usman, W. Ahmad, M.H. Bacha, A. Zafar and S.K.Bukhari (2019). “A shift from logistic software to service model: A case study of new service -driven-software for management of emergency supplies during disasters and emergency conditions by WHO”. Frontiers Pharmacology 10(473)
  9. Bilal, R., M. Usman, AM Khan, W. Latif, N.A. Ahmad and S. Riffat (2018). “Development and validation of a chromatographic method for quantification of rasagiline in human plasma”. Trop J Pharm Res 17(11): 2243-2248.
  10. Safdar, Z., M. Usman, S.S.H. Sherazi, D. Shahwar and H. Rasheed (2018). “In Vitro Interaction Study of Diclofenac Sodium and Acetaminophen with Herbal Agents” Lat Am J Phar 37(10): 1993-1996
  11. Usman, M., M. Fobker and G. Hempel (2018). "Investigation of the age dependency of vancomycin clearance by population pharmacokinetic modeling." Int J Clin Pharmacol Ther 56(2): 56-63
  12. Usman, M., O. R. Frey and G. Hempel (2017). "Population pharmacokinetics of meropenem in elderly patients: dosing simulations based on renal function." Eur J Clin Pharmacol 73(3): 333-342.
  13. Usman, M. and G. Hempel (2016). "Development and validation of an HPLC method for the determination of vancomycin in human plasma and its comparison with an immunoassay (PETINIA)." Springerplus 5: 124.
  14. Abbas, M., A. M. Khan, S. Riffat, M. Y. Tipu, H. A. Nawaz and M. Usman (2014). "Assessment of sex differences in Pharmacokinetics of carvedilol in human." Pak J Pharm Sci 27(5): 1265-1269
  15. Usman M, Ashraf M, Khokhar MI, Ashiq B, Masood MI, Afzal S, Omer O, Ali M and Qadir MI. 2013. Comparative pharmacokinetics of levofloxacin in healthy volunteers and in patients suffering from typhoid Fever. Iran J Pharm Res. 12(1): 147-154.
  16. Ashiq, B., M. Usman, M. Ashraf, O. Omer, M. I. Khokhar and and S. Saeed-ul-Hassan (2011). "Comparative pharmacokinetics of metronidazole in healthy volunteers and in patients suffering from Amoebiasis." Pak J Pharm 24(1&2): 41-46

 

 

Conferences / workshops Organized

  • Organized 1st National Workshop on Sterile compounding and Aseptic Techniques: A special Focus on Handling of Hazardous Medication” on 2nd January 2019 at Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore.
  • Organized 35th EORTC-PAMM Winter Meeting, Münster, Germany 12-15 February 2014, as a member of local organizing committee of Clinical Pharmacy working group.
  • A Workshop on introduction to Population Pharmacokinetics with Non-Linear Mixed Effect Modelling (NONMEM®) on 28th October 2019 during International Pharmacy Conference and Exhibition (IPCE) 2019. As resource person
  • Organized A workshop on “Simulation techniques in drug development” organized at Institute of Pharmaceutical Sciences, UVAS, Lahore on 20th December, 2017.

 

 

Conferences

  • 1st Asian Pharmacometrics Conference (APC) held in Kyoto, Japan 26th to 27th October 2017.
  • 25th annual meeting of Population Approach Group of Europe (PAGE) held in Lisbon, Portugal 7th to 10th June 2016.
  • Annual meeting of German Pharmaceutical Society – DPhG held at Goethe University Frankfurt Germany from 24th to 26th September 2014.
  • Organized 35th EORTC-PAMM Winter Meeting, Münster, Germany 12-15 February 2014, as a member of local organizing committee of Clinical Pharmacy working group.

Workshops

  • A workshop on “Simulation techniques in drug development” organized at Institute of Pharmaceutical Sciences, UVAS, Lahore on 20th December, 2017.

Conferences / workshops participated 

Oral Presentations

  • Usman M. Dose optimization of vancomycin through population pharmacokinetic modelling in Pakistani patients. Oral presentation at 1st International conference on Innovations in Pharmacy, Giving Back to Pharmacy in Pakistan (GBTPP)” held online on 18-19 September 2020.
  • Usman, M. and G. Hempel (2017). " Population Pharmacokinetics for Investigation of the age dependency of vancomycin clearance. Oral presentation at 1st Asian Pharmacometrics Conference (APC) held in Kyoto, Japan 26th to 27th October 2017.
  • Usman, M. and G. Hempel (2017). " Investigation of the age dependency of vancomycin clearance by population pharmacokinetic modeling. Oral presentation at 1st International Conference on Recent Advances in Clinical Research (RACR) held in department of Physiology, University of Veterinary and Animal Sciences, Lahore, Pakistan. 19th to 20th December 2017.
  • Usman, M. and G. Hempel (2018). "Population pharmacokinetics of meropenem in elderly patients: dosing simulations based on renal function. Oral Presentation in 2nd International Conference of Shalamar Medical & Dental College Lahore held on 03-04 February 2018 at Shalamar Medical & Dental College.
  • Usman, M. (2018). "Population pharmacokinetics and dosing simulations of meropenem based on Creatinin Clearance of Patients. Oral presentation at 1st GRIP’s International Conference of Pharmaceutical and Biomedical Sciences, held in Expo Centre Lahore. 22nd and 23rd and 24th  January 2018.
  • Usman, M. (2018). "Population pharmacokinetics of meropenem in different disease conditions. Oral presentation at 1st National Conference in Recent Advancements in Pharmaceutical Sciences held at University of Sargodha, Pakistan. 7th and 8th March 2018.

Poster Presentations

  • Usman M. Dose optimization of meropenem through population pharmacokinetic modelling in Pakistani patients. Poster/short oral presentation at Pharmacometrics Japan Conference 2020 held on 22nd and 23rd of January 2020 in Keio University School of medicine, Department of Clinical Pharmacokinetics and Pharmacodynamics, Tokyo, Japan.
  • Usman, M. and G. Hempel (2016). "Population pharmacokinetics of meropenem in elderly patients: dosing simulations based on renal function. Poster presentation at 25th annual meeting of Population Approach Group of Europe (PAGE) held in Lisbon, Portugal 7th to 10th June 2016.
  • Usman, M. and G. Hempel (2016). " Development and validation of an HPLC method for the determination of vancomycin in human plasma and its comparison with PETINIA. Poster presentation at annual meeting of German Pharmaceutical Society – DPhG held at Goethe University Frankfurt Germany from 24th to 26th September 2014.
  • Mamoona Tariq, Sualeha Riffat and Muhamamd Usman (2017). “Method validation and Pharmacokinetics of carvedilol in healthy volunteers”. Poster presentation at a three days international conference on “Current research in Chemical and Pharmaceutical Sciences ” held at FC college Lahore from 18th to 20th January 2017.

 Trainings

  • Two days Workshop on “Patent Drafting” organized by Office of Research, Innovation and Commercialization (ORIC) and sponsored by the In Service Training of Veterinary Faculty for Professional Development (IVPD) Project. held on the 18th-19th June, 2019 at Conference Hall, UVAS, Lahore.

 

 

 

Projects

As principal investigator

Sr. No

Title of Project

Co-PI

Program

Amount

Status

1

Population Pharmacokinetics of Vancomycin in Pakistani Patients.

Dr. Aqeel Javeed

Start Up Research Grant (SRGP) Program by HEC

0.487 Million

Completed

2

Poultation Pharmacokinetics of Antibiotics in Pakistani Patients

Dr. Mateen Abbas

National Research Program for Universities (NRPU) by HEC

1.983 Million

On Going

 

As Co-principal investigator

Sr. No

Title of Project

PI

Program

Amount

Status

1

In-silico exploration of 6‑Substituted 2‑Arylaminopurines selectivity for CDK2 and CDK1 through Linear Interaction energy (LIE) and molecular dynamics simulations

Dr. Tahir Ali Chohan

Start Up Research Grant (SRGP) Program by HEC

0.5 Million

Completed

Laboratory Development

Developed Pakistan’s first Pharmacometrics lab for carrying out research on Population Pharmacokinetic (popPK) modelling, Pharmacokinetic Pharmacodynamic (PKPD) modelling and  Physiologically Based Pharmacokinetic (PBPK) modelling.

Development of new courses

Sr. No.

                Course No.

                       Course Title

                Class

      Credit Hours

1

PHCU 1021

Population pharmacokinetic Modelling

M.Phil (Pharmaceutics)

3(2-1)