Assistant Professor
B. Pharm (University of the Punjab, Pakistan),
M. Phil Pharmacology & Toxicology (UVAS, Pakistan),
PhD (University of Muenster, Germany)
Tel: +92-42-99214341
Mobile: +92-333-4548265
Email: usman.ips@uvas.edu.pk
Biography
Dr. Muhammad Usman, is Assistant Professor at Institute of Pharmaceutical Sciences (IPS), University of Veterinary & Animal Sciences, Lahore, Pakistan. He got B.Pharmacy degree from University of the Punjab in 2005 and M.Phil in Pharmacology and Toxicology from University of Veterinary and Animal Sciences, Lahore in 2008. He went to Germany in 2013 and completed his doctoral degree in December 2016 from University of Muenster, Germany.
He started his professional career in Feb 2006 as Community Pharmacist and served at Himont Pharmacy Gujranwala as Branch Manager for 9 months. Then he joined Doctor’s Hospital and Medical Centre as retail Pharmacist on 02-11-2006 and worked till 07-11-2008.
Immediately after completion of his M.Phil in 2008 he joined Institute of Pharmaceutical Sciences, UVAS as Lecturer on 08-11-2008 and was a member of pioneer team in the establishment of this esteemed Institute.
He is also a part of Bioequivalence Study Center (BeSt Center), UVAS, Lahore. He is skillful in conducting clinical trials for Bioequivalence studies and quantification of drugs in biological fluids through HPLC.
The research title of his M.Phil Thesis was “Comparative pharmacokinetics of Levofloxacin in Healthy Volunteers and in Patients Suffering from Typhoid Fever”. During M.Phil he got hands on training of clinical trials and quantification of drug concentrations in human plasma by using HPLC.
The area of research in Doctoral study is Population Pharmacokinetics in Elderly Patients. He got a good experience of working on different Pharmacokinetic software including NONMEM® and PK-Sim®. He is the Pioneer Pharmacometrician who is introducing this technique in Pakistan and has developed Pakistan’s 1st ever Pharmacometrics Laboratory at IPS, UVAS.
Dr. Muhammad Usman is representing Pakistan in Asian Pharmacometrics Network (APN) as Board member. He has also represented Pakistan as Pharmacometrician at different scientific forums in Pakistan and across the globe.
Area of Interest
- Population Pharmacokinetics (popPK) modelling
- Physiologically Based Pharmacokinetics (PBPK)
- Quantification of drug concentrations in biological fluids by HPLC, LC-MS, Immunoassays
- Quantification of drugs in blood by Dried Blood Spot (DBS) technique.
- Bioequivalence studies
- Pharmacovigilance
- Availability of essential medicines
Publications
- Usman M, Shaukat QUA, Khokhar MI, Bilal R, Khan RR, Saeed A, Ali M, Khan HM. Comparative pharmacokinetics of valproic acid among Pakistani and South Korean patients: A population pharmacokinetic study. PLoS ONE 2022. 17(8)
- Kaibara A, Peng A, Xie R, Ho YF, Lin CJ, Tham LS, Mallayasamy S, Sathirakul K, Lo YL, Tran MH, Pham VT, Kharis Nugroho A, Myo Oo K, Kunwar B, Mannapperuma U, Ya K, Usman M, Ming LC, Park K. The Asian Pharmacometrics Network: The historical background, establishment, objectives and roles, and recent activities. CPT Pharmacometrics Syst Pharmacol. 2022. org/10.1002/psp4.12777
- Munir MM, Rasheed H, Khokhar MI, Khan RR, Saeed HA, Abbas M, Ali M, Bilal R, Nawaz HA, Khan AM, Qamar S, Anjum SM, Usman M*. Dose Tailoring of Vancomycin Through Population Pharmacokinetic Modeling Among Surgical Patients in Pakistan. Frontiers in Pharmacology. 2021; 12. DOI: 10.3389/fphar.2021.721819.
- Rasool MF, Ali S, Khalid S, Khalid R, Majeed A, Imran I, Saeed H, Usman M, Ali M, Alali AS, AlAsmari AF, Ali N, Asiri AM, Alasmari F, Alqahtani F. Development and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases. Scientific Reports. 2021; 11:8589. DOI: 10.1038/s41598-021-88154-2.
- Rafi S, Rasheed H, Usman M, Nawaz HA, Anjum SM, Chaudhry M, Babar ZU. Availability of essential medicines in Pakistan-A comprehensive document analysis. PLoS One. 2021; 16:e0253880. DOI: 10.1371/journal.pone.0253880.
- Zaman M, Khan HM, Usman M*, Khokhar MI, Rasheed H, Abbas M, Khan RR, Saleem R. Population pharmacokinetics of meropenem among post-operative patients in Pakistan. Int J Clin Pharmacol Ther. 2021. DOI: 10.5414/cp203790.
- Saleem R, Khan HM, Usman M*, Khokhar MI, Rasheed H, Abbas M, Khan RR, Zaman M, Maqsood Z. Population pharmacokinetics of ciprofloxacin in Pakistani patients suffering from enteric fever. Int J Clin Pharmacol Ther. 2021; 59:47-54. DOI: 10.5414/cp203823.
- Khan QU, Siddique MI, Rasool F, Naeem M, Usman M, Zaman M. Development and characterization of orodispersible film containing cefixime trihydrate. Drug Dev Ind Pharm. 2020; 46:2070-2080. DOI: 10.1080/03639045.2020.1843477.
- Waqas MK, Ali R, Usman M, Nabeel M, Shahid AR, Khan BA, Murtaza G. In Vitro Comparative Dissolution Assessment of Different Brands of Co-Amoxiclav Tablets in Pakistan. DISSOLUTION TECHNOLOGIES. 2020; 27:1-8.
- Ali M, Usman M*, Rasheed H, Hempel G, Nawaz HA, Hanif M, Rasool F, Saleem M. A systematic review on chromatography-based method validation for quantification of vancomycin in biological matrices. Bioanalysis. 2020; 12:1767-1786. DOI: 10.4155/bio-2020-0230.
- Khadka S, Hashmi FK, Usman M. Preventing COVID-19 in low- and middle-income countries. Drugs Ther Perspect. 2020:1-3. DOI: 10.1007/s40267-020-00728-8.
- Khan MT, Usman M*, Nawaz HA, Rasheed H, Khan RR, Anjum SMM, Khokhar MI, Akhtar N. Formulation of Phaseolus vulgaris L. cream and its characterization. Pak J Pharm Sci. 2020; 33:815-820.
- Nawaz HA, Masood MI, Abbas M, Usman M, Khan AM, Rasheed H, Riffat S. Evaluation of gender difference in pharmacokinetics of Candesartan cilexetil in the fasted state by RP-HPLC: A single dose comparative study. Pak J Pharm Sci. 2019; 32:1019-1024.
- Rasheed H, Usman M, Ahmed W, Bacha MH, Zafar A, Bukhari KS. A Shift From Logistic Software to Service Model: A Case Study of New Service-Driven-Software for Management of Emergency Supplies During Disasters and Emergency Conditions by WHO. Front Pharmacol. 2019; 10:473. DOI: 10.3389/fphar.2019.00473.
- Safdar Z, Usman M*, Sherazi SSH, Shahwar D, Rasheed H. In Vitro Interaction Study of Diclofenac Sodium and Acetaminophen with Herbal Agents. Latin American Journal of Pharmacy. 2018; 37:1993-1996.
- Usman M, Fobker M, Hempel G. Investigation of the age dependency of vancomycin clearance by population pharmacokinetic modeling. Int J Clin Pharmacol Ther. 2018; 56:56-63. DOI: 10.5414/CP203033.
- Usman M, Frey OR, Hempel G. Population pharmacokinetics of meropenem in elderly patients: dosing simulations based on renal function. Eur J Clin Pharmacol. 2017; 73:333-342. DOI: 10.1007/s00228-016-2172-4.
- Usman M, Hempel G. Development and validation of an HPLC method for the determination of vancomycin in human plasma and its comparison with an immunoassay (PETINIA). Springerplus. 2016; 5:124. DOI: 10.1186/s40064-016-1778-4.
- Abbas M, Khan AM, Riffat S, Tipu MY, Nawaz HA, Usman M. Assessment of sex differences in Pharmacokinetics of carvedilol in human. Pak J Pharm Sci. 2014; 27:1265-1269.
- Usman M, Ashraf M, Khokhar MI, Ashiq B, Masood MI, Afzal S, Omer O, Ali M, Qadir MI. Comparative pharmacokinetics of levofloxacin in healthy volunteers and in patients suffering from typhoid Fever. Iran J Pharm Res. 2013; 12:147-154.
- Ashiq B, Usman M*, Ashraf M, Omer O, Khokhar M I, Hassan S S H. Comparative Pharmacokinetics of Metronidazole in Healthy Volunteers and in Ptients Suffering from Amoebiasis. Pakistan Journal of Pharmacy. 2011; 24:41-46
- Usman M. Dose optimization of vancomycin through population pharmacokinetic modelling in Pakistani patients. Oral presentation at 1st International conference on Innovations in Pharmacy, Giving Back to Pharmacy in Pakistan (GBTPP)” held online on 18-19 September 2020.
- Usman, M. and G. Hempel (2017). ” Population Pharmacokinetics for Investigation of the age dependency of vancomycin clearance. Oral presentation at 1st Asian Pharmacometrics Conference (APC) held in Kyoto, Japan 26th to 27th October 2017.
- Usman, M. and G. Hempel (2017). ” Investigation of the age dependency of vancomycin clearance by population pharmacokinetic modeling. Oral presentation at 1st International Conference on Recent Advances in Clinical Research (RACR) held in department of Physiology, University of Veterinary and Animal Sciences, Lahore, Pakistan. 19th to 20th December 2017.
- Usman, M. (2018). “Population pharmacokinetics of meropenem in elderly patients: dosing simulations based on renal function. Oral Presentation in 2nd International Conference of Shalamar Medical & Dental College Lahore held on 03-04 February 2018 at Shalamar Medical & Dental College.
- Usman, M. (2018). “Population pharmacokinetics and dosing simulations of meropenem based on Creatinin Clearance of Patients. Oral presentation at 1st GRIP’s International Conference of Pharmaceutical and Biomedical Sciences, held in Expo Centre Lahore. 22nd and 23rd and 24th January 2018.
- Usman, M. (2018). “Population pharmacokinetics of meropenem in different disease conditions. Oral presentation at 1st National Conference in Recent Advancements in Pharmaceutical Sciences held at University of Sargodha, Pakistan. 7th and 8th March 2018.
- Usman M, Munir MM, Rasheed H. Population pharmacokinetics of vancomycin in Pakistani patients: Dosing simulations based on renal status. Poster presentation at Annual meeting of Population Approach in Group Europe (PAGE 2021) held online from 2nd September to 7th September 2021
- Usman M. Dose optimization of meropenem through population pharmacokinetic modelling in Pakistani patients. Poster/short oral presentation at Pharmacometrics Japan Conference 2020 held on 22nd and 23rd of January 2020 in Keio University School of medicine, Department of Clinical Pharmacokinetics and Pharmacodynamics, Tokyo, Japan
- Usman, M. and G. Hempel (2016). “Population pharmacokinetics of meropenem in elderly patients: dosing simulations based on renal function. Poster presentation at 25th annual meeting of Population Approach Group of Europe (PAGE) held in Lisbon, Portugal 7th to 10th June 2016.
- Usman, M. and G. Hempel (2016). ” Development and validation of an HPLC method for the determination of vancomycin in human plasma and its comparison with PETINIA. Poster presentation at annual meeting of German Pharmaceutical Society – DPhG held at Goethe University Frankfurt Germany from 24th to 26th September 2014.
- Mamoona Tariq, Sualeha Riffat and Muhamamd Usman (2017). “Method validation and Pharmacokinetics of carvedilol in healthy volunteers”. Poster presentation at a three days international conference on “Current research in Chemical and Pharmaceutical Sciences ” held at FC college Lahore from 18th to 20th January 2017.
- Usman M, Rasheed H, “Pharmacometrics and its application in clinical practice” Encyclopaedia of Pharmacy Practice and Clinical Pharmacy, Babar, Z-U-D (2019). Ed.1st Vol 3B: 227-238. ISBN: 9780128127353.
- Usman M, Rasheed H, Clinical pharmacokinetics and therapeutic drug monitoring, Encyclopaedia of Pharmacy Practice and Clinical Pharmacy, Babar, Z-U-D (2019). Ed.1st Vol 3A:8-19. ISBN: 9780128127353 Ed.1st Vol 3:8-19
- Rasheed H, Nawaz MA, Usman M, Anjum SM, Epilepsy-role of pharmacist in management and control, Encyclopaedia of Pharmacy Practice and Clinical Pharmacy, Babar, Z-U-D (2019). Ed.1st Vol 3A:598-618, ISBN: 9780128127353
Research Grants
As Principal Investigator |
|||
Title |
Funding agency | Amount | Status |
Population Pharmacokinetics of Vancomycin in Pakistani Patients. | Higher Education Commission of Pakistan
under Start Up Research Grant (SRGP) Program |
PKR
0.5 Million |
Completed |
Population Pharmacokinetics of Antibiotics in Pakistani Patients. | Higher Education Commission of Pakistan
Under National Research Program for Universities (NRPU) |
PKR
1.983 Million |
Completed |
As Co-Principal Investigator |
|||
In-silico exploration of 6‑Substituted 2‑Arylaminopurines selectivity for CDK2 and CDK1 through Linear Interaction energy (LIE) and molecular dynamics simulations | Higher Education Commission of Pakistan
under Start Up Research Grant (SRGP) Program |
PKR
0.5 Million |
Completed |
Development of stem cell therapy for treating cutaneous wounds in canines: a translational model for humans |
Higher Education Commission of Pakistan
Under National Research Program for Universities (NRPU) |
6.135 Million | On Going |
Determination of N-Nitroso dimethyl amine in amine-based anti-hypertensive drugs and their association with cancer | Higher Education Commission of Pakistan
Under National Research Program for Universities (NRPU) |
5.096 Million | On Going |
Professional Trainings
- Professional Competency Enhancement Program for Teachers (PCEPT) held at University of Veterinary and Animal Sciences, Lahore from Feb 02 to March 02, 2011. Organized by Higher Education Commission (HEC) of Pakistan, National Academy of Higher Education.
- Post Graduate Course for Higher Education Learning and Teaching (PGC-HELT) October 2020 to March 2021, organized by Faculty of Bio-Sciences, University of Veterinary and Animal Sciences, Lahore.
Membership of International Networks
Board member of Asian Pharmacometrics Network (APN) as representative of Pakistan
Students Supervision
Student’s name |
Thesis title |
Status |
Muhammad Ahmad Aaqib
(2017-VA-45) |
Formulation development and evaluation of gastro-resistant tablet of ifosfamide using beta-cyclodextrin and hydroxylpropyl methylcellulose | Completed
(2019) |
Muhammad Muaaz Munir
(2011-VA-729) |
Population pharmacokinetics of vancomycin in Pakistani patients | Completed
(2019) |
Muhammad Noman Akram
(2011-VA-731) |
Therapeutic drug monitoring of vancomycin through validated HPLC method | Completed
(2020) |
Ammara Arif
(2012-VA-732) |
Population pharmacokinetics of moxifloxacin in Pakistani patients | Completed
(2020) |
Syeda Zia-ul-Ain Bukhari
(2018-VA-65) |
Simultaneous quantification of moxifloxacin and linezolid in human plasma using HPLC | Completed
(2020) |
Asim Ali
(2011-VA-728) |
Formulation development and in-vitro characterization of solid dispersion tablets of carbamazepine for enhancing bioavailability | Completed
(2021) |
Syed Ehsan ul Haq
(2019-mphil-1176) |
Population pharmacokinetics of Vancomycin in elderly patients from pooled clinical data | Completed
(2021) |
Faiza Urooj
(2019-mphil-1179) |
Risk based prioritization of essential antimicrobial agents based on BCS classification and review of bioanalytical methods for mandatory bioequivalence status | Completed
(2021) |
Hammad Ahmad
(2019-mphil-1205) |
A comparative study on non-prescription dispensing of antibiotics and narcotics at drug sale outlets in urban areas of Lahore | Completed
(2021) |
Annum Maha
(2019-mphil-2141) |
Population Pharmacokinetics of linezolid in Pakistani Patients | Completed
(2022) |
Akasha Jamshaid
(2015-VA-294) |
Impact of pharmacist's interventions in ensuring therapeutic outcomes of anti-tuberculosis drugs in TB patients with comorbidities in a public sector health facility | Completed
(2022) |
As Co-Supervisor | ||
Student’s name | Thesis title | Status |
Rabia Saleem
(17-M/LCWU-16) |
Population pharmacokinetics of ciprofloxacin among indoor patients of tertiary care hospitals, Lahore, Pakistan
|
Completed
(2020) |
Madiha Zaman
(17-M/LCWU-11) |
population pharmacokinetics of meropenem among post-operative patients
|
Completed
(2020) |
Qurrat-ul-Ain Yousaf
(17-M/LCWU-14) |
Comparative population pharmacokinetics of valproic acid in Pakistani patients and Korean patients
|
Completed
(2020) |
Sitaram Khadka
15-MCol-M19a
|
Comparative pharmacokinetics of meropenem in young and elderly patients through a non-linear mixed effect modelling approach | Completed
(2022) |
As Member of Supervisory Committee |
||
Student’s name |
Thesis title |
Status |
Muhammad Shahwar
(2009-VA-017) |
Evaluation of Good Pharmacy Practice in
Community Drug Sale outlets with "A" Category License in the Urban Lahore. |
Completed
(2011) |
Asad Ali Lodhi
2009-VA-343 |
Study for detection, evaluation, and strategies to minimize medication errors in tertiary care teaching hospitals Lahore | Completed
(2019) |
Rehan Ali
2009-VA-343 |
Comparison of in-vitro drug release of different brands of Co-amoxiclave using HPLC method | Completed
(2019) |
Qurrat-ul-Ain Khan
2017-VA-98 |
Development and characterization of orodispersible film containing cefixime trihydrate as a model drug | Completed
(2019) |
Sadaf Aroosa
2017-Mphil-1591 |
Impact of dexmedetomidine infusion on isoflurane induced oxidative stress and DNA damage in patients undergoing major emergency surgery | Completed
(2019) |
Iffat Akhtar
2013-VA-291 |
Investigation of efficacy of complementary and alternative medicine for peripheral arterial disease: A systematic review and meta-analysis | Completed
(2021) |
Yasmeen Iqbal
2019-mphil-1182 |
Population Pharmacokinetics of meropenem in adult patients from pooled clinical data | Completed
(2021) |
Zunair Maqsood
2019-mphil-1185 |
Challenges and Opportunities in sustainability of Bioequivalence Study Centers in Pakistan | Completed |
Asma Rabail
2019-mphil-1188 |
Formulation of Doxorubicin loaded PLGA Nanoparticles for gastric cancer using Thiolated Hydroxy Ethyl Cellulose | Completed
(2021) |
Muhammad Bilal Saeed
2020-VA-308 |
Impact of interventions by ward pharmacist in tertiary care teaching hospital on medication use pattern and safety using action research
|
On Going |
Umaira Israr
2020-VA-1484 |
Prices, availability, and affordability study of essential antifungal, antiviral and antiparasitic medicines in Lahore, Pakistan using WHO/HAI Methodology
|
Completed
(2022) |
Nawal Nida
2014-VA-158 |
Analysis of drug-drug interactions in outpatient department of charity based hospital | Completed
(2022) |
Muhammad Chaudhry
2014-VA-137 |
Formulation of thiolated mucoadhesive intravesical nanpoparticles for bladder cancer | Completed
(2022) |
Laboratory Development
Developed Pakistan’s first Pharmacometrics lab for carrying out research on Population Pharmacokinetic (popPK) modelling, Pharmacokinetic Pharmacodynamic (PKPD) modelling and Physiologically Based Pharmacokinetic (PBPK) modelling.
Development of New Courses
Sr. No. |
Course No. |
Course Title |
Class |
Credit Hours |
1 |
PHCU 1021 |
Population pharmacokinetic Modelling |
M.Phil (Pharmaceutics) |
3(2-1) |