Dr. Tahir Ali Chohan

Assistant Professor
B.Pharm (BZU, Pakistan), MPhil. Pharm. Chem. (IUB, Pakistan), PhD. Med. Chem. (ZJU, China)
Tel: 00 92 42 9921 1449 (Ext 308)
Mobile:
Email: tahir.chohan@uvas.edu.pk

Biography

To date Dr. Chohan has more than five years of job experience in research/development, quality control, teaching and research. He started his carrier in 2010 as a quality control (QC) pharmacist, from a national pharmaceutical firm ZAKFAS Pvt, Ltd. Pakistan. Soon after he adopted teaching as career in 2011 and joined faculty of pharmacy, the University of Lahore (UOL), which is a renowned private sector university in Pakistan. In year 2016 he joined faculty of pharmacy, University of Central Punjab, as assistant professor and HOD of pharmaceutical chemistry department. On October 2017, he joined Institute of Pharmaceutical Sciences (IPS), University of Veterinary and Animal Sciences as Assistant Professor. Currently, he is engaged in teaching medicinal chemistry to undergrad students and in supervision of M.Phil. Students.
His current research interests include molecular simulation of any systems of pharmaceutical and biological interest, design of new bio-active molecules using computer aided modeling techniques, modeling of small organic molecules, proteins, and protein-ligand interactions, protein-protein interactions, ligand based and structure based pharmacophore design, molecular dynamics simulations, MMGB/PBSA and QM/MM calculations, free energy calculation with free energy workflow (FEW). To date he has published more ten research papers in ISI-cited journals with a cumulative impact factor of 20. He has authored various book chapters published by tire one publishers.

Areas of Interest

    1. Chemical constituents of Medicinal Plants.
    2. Design of new bio-active molecules using computer aided modelling techniques.
    3. Modelling of small organic molecules, proteins, and protein-ligand interactions.
    4. Ligand based and structure based pharmacophore design.
    5. Generation and screening of large virtual combinatorial compound libraries.
    6. Molecular activity determination using 3D-QSAR or quantum chemistry calculations.
    7. Molecular Dynamics (MD) simulations studies of protein-ligand complex.

Publications

 

Papers published in 2018

  1. Rehman, K.; Chohan, T.A.; Waheed, I.; Gilani, Z.; Akash, M.S.H., Taxifolin prevents postprandial hyperglycemia by regulating the activity of α‐amylase: Evidence from an in vivo and in silico studies. Journal of cellular biochemistry, 2018. (IF=2.96)
  2. Chohan, T.A.; Qayyum, A.; Rehman, K.; Tariq, M.; Akash, M.S.H., An insight into the emerging role of cyclin-dependent kinase inhibitors as potential therapeutic agents for the treatment of advanced cancers. Biomedicine & Pharmacotherapy, 2018, 107, 1326-1341. (IF=3.21).
  3. Chohan, T.; Chohan, T.; Zhou, L.; Yang, Q.; Min, L.; Cao, H., Repellency, Toxicity, Gene Expression Profiling and In Silico Studies to Explore Insecticidal Potential of Melaleuca alternifolia Essential Oil against Myzus persicae. Toxins, 2018, 10, (11), 425. (IF=3.54).

 

Papers published in 2017

  1. Aziz-ur-Rehman, N Ahtzaz, MA Abbasi, NAVirk, Chohan, T.A, SAA Shah, Synthesis of Some new Propanamide Derivatives Bearing 4-Piperidinyl-1,3,4-oxadiazole as Valuable Anticancer Agents. (IF=0.56).

Papers published in 2016

  1. Chohan, T.A.; Chen, J.-J.; Qian, H.-Y.; Pan, Y.-L.; Chen, J.-Z., Molecular modeling studies to characterize N-phenylpyrimidin-2-amine selectivity for CDK2 and CDK4 through 3D-QSAR and molecular dynamics simulations. Molecular BioSystems, 2016, DOI: 10.1039/c5mb00860c. (IF=3.21).
  2. Chohan, T.A.; Qian, H.-Y.; Pan, Y.-L.; Chen, J.-Z., Molecular simulation studies on the binding selectivity of 2-anilino-4-(thiazol-5-yl)-pyrimidines in complexes with CDK2 and CDK7. Molecular BioSystems, 2016, 12, (1), 145-161. (IF=3.21).

Papers published in 2015

  1. Chohan, T.A.; Qian, H.; Pan, Y.; Chen, J.-Z., Cyclin-Dependent Kinase-2 as a Target for Cancer Therapy: Progress in the Development of CDK2 Inhibitors as Anti-Cancer Agents. Current Medicinal Chemistry, 2015, 22, (2), 237-263. (IF=3.87).

Papers published in 2012

  1. Murtaza, G.; Azhar, S.; Khalid, A.; Nasir, B.; Ubaid, M.; Shahzad, M.K.; Saqib, F.; Afzal, I.; Noreen, S.; Tariq, M.; Chohan, T.A.; Malik, A. Development of in vitro in vivo correlation for pharmacokinetic simulation. African Journal of Pharmacy and Pharmacology, 2012, 6(4), 257-263. (IF= 0.84).

 

 

Awards and distinctions 

  1. Selected as a Ph.D. Candidate for Chinese Government Scholarship (CSC), at Zhejiang University, China.

 

Graduate Student Supervision

            Supervised:

  1. 2 M.Phil. Students as supervisor

           Under Supervision:

  1. 2 M.Phil. Students as Supervisor

Projects

Author(s) and brief title of grant

Funding body / Investigator

Year

Value

In-silico exploration of 6‑Substituted 2‑Arylaminopurines selectivity for CDK2 and CDK1 through Linear Interaction energy (LIE) and molecular dynamics simulations.
 

Higher Education Commission, Pakistan

2018

0.5 million PKR